Vitiligo is a chronic skin disorder that causes areas of skin to lose colour. It presents as depigmented (white) patches. Exposed body sites, such as the face, elbows, knees, hands and feet, are often involved, resulting in significant cosmetic concerns. Vitiligo is usually treated with creams and tablets, or by phototherapy. Vitiligo may fail to improve or clear with these treatments.
Different types of vitiligo surgery?
All types of surgical treatment aim to transfer melanocytes (pigment-producing cells) from normal skin (the donor site) to the skin affected by vitiligo:-
1. Grafting of melanocyte-rich tissue(a). Miniature punch grafting
Miniature punch grafting is one of the most commonly used techniques, due to its simplicity and efficacy. Bits of skin about 2 mm in diameter are punched out from the donor site on buttock or thigh and placed on the donor site of vitiliginous skin, where recipient chambers have also been created by punches.
Potential immediate complications of miniature punch grafting include:
- i. Loss of graft tissue
- ii. Infection
(b). Suction blister grafting
In suction blister grafting, negative pressure is applied to the normally pigmented donor site to promote the formation of multiple blisters.
Blisters may be raised using one of the following options:
- i. Syringe
- ii. Suction pump
- iii. Suction cups
- iv. Negative pressure cutaneous suction chamber system
The bases of syringes of sizes 10 ml and 20 ml are coated with vaseline and are applied on the donor site. It usually takes 1.5 to 2.5 hours for the development of blisters. The roofs of the blisters (the grafts) are surgically removed, cut to the appropriate size and shape, and transplanted onto the prepared recipient site. Good cosmetic results can be achieved, with minimal scarring of the donor site or cobblestoning at the recipient site. Suction blister grafting is generally safe, easy to perform and inexpensive, with good success rates. However, it can also be very time consuming, and can be performed only on small areas of skin.
(c). Split thickness skin grafting
Split thickness skin grafting involves shaving off thin layers of skin from the donor site. In comparison to punch grafting and suction blister grafting, split thickness skin grafting can cover larger areas and produces uniform pigmentation with no cobblestoning.
Complications of split thickness skin grafting include:
- i. Hyperpigmentation
- ii. Peripheral depigmentation
- iii. Milia formation
- iv. Graft rejection
2. Grafting of melanocyte cell suspensions(a). Miniature punch grafting
Autologous non-cultured epidermal cell suspensions are gaining popularity around the world as the treatment of choice for surgical management of vitiligo. Pre-prepared kits are available. Tissue is harvested from a donor site and is incubated with trypsin to separate the epidermis from the dermis. The melanocytes are then separated from the epidermis and made into a cell suspension that can then be transplanted onto the de-epithelialized recipient skin. Autologous non-cultured epidermal cell suspensions allow large areas to be treated in one session using a small donor graft. They result in excellent colour matching. However the procedure is expensive and complex. Due to stringent rules regarding tissue handling in Australia and elsewhere, it is not yet widely available.
(b). Cultured melanocyte suspensions
In suction blister grafting, negative pressure With cultured melanocyte suspensions, tissue is also harvested and incubated with trypsin. However, after separation of the epidermis, the melanocytes and keratinocytes are incubated in a medium containing growth factors. The cultured suspension is then transplanted on to de-epithelialized recipient skin. Cultured melanocyte suspensions allow a large area to be treated in a single session. It uses a larger donor-to-recipient ratio than the non-cultured technique. This sophisticated technique requires a special laboratory.